Common Features of Neurodegenerative Diseases

​​Tuesday, March 28, 2017

08:30 -17:30

Pre-Conference Full Day Satellite Workshop

COMMON FEATURES OF NEURODEGENERATIVE DISEASES: EXPLORING THE BRAIN-EYE CONNECTION AND BEYOND

Co-Chairs: Guojun Bu, PhD, Adriana Di Polo, PhD, Todd E. Golde, MD, PhD

Interdisciplinary research to compare and contrast human diseases is a key component of many academic and industry research programs. This workshop is intended to provide the participant with an understanding of the common and distinct features of neurodegenerative diseases, which include not only those affecting the brain, such as Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, frontotemporal dementia, vascular dementia, and mixed dementia; but also the ocular diseases including age-related macular degeneration, glaucoma, and diabetic retinopathy. This working group seeks to discuss and identify knowledge and barriers to bridging ocular neuroscience with the broader field of neurodegenerative diseases, and provide thoughtful guidance to investigators seeking to meaningfully incorporate the idea of interdisciplinary research in their own research programs.

8:30—8:45  INTRODUCTORY REMARKS

SESSION I - APOE AND LIPID METABOLISM IN HEALTH AND NEURODEGENERATIVE DISEASES (Moderator: Guojun Bu)

8:45-9:00         1) Alison Goate (Icahn School of Medicine at Mount Sinai, NY, USA)
Topic:  APOE as a risk factor for AD and ocular diseases.

9:00-9:05         Q & A

9:05-9:20         2) Guojun Bu (Mayo Clinic Jacksonville, USA)
Topic:  APOE in lipid metabolism and injury repair.

9:20-9:25         Q & A

9:25-9:40         3) Marco Colonna (Washington University in St. Louis, USA)
Topic:  APOE/lipid sensing by TREM2 in microglia.

9:40-9:45         Q & A

9 :45-10:00      4) Florian Sennlaub (Institut de la Vision, Paris, France)
Topic: APOE isoforms and age-related macular degeneration.

10:00-10:05     Q & A

10 :05-10 :20   5) Karl Fernandes (University of Montreal, Canada)
Topic: Lipid metabolism and adult neural stem cells in AD.

10:20-10:25     Q & A

10:25-10:45 am Section I Discussion/Q&A

10:45-11:00am      COFFEE BREAK

 

SESSION II - COMPLEMENT CASCADE/NEUROINFLAMMATION (Moderator: Todd Golde)

11:00-11:15     1) Michael Heneka (DZNE, Germany)
General: Neuroinflammation in Neurodegenerative Disease

11:15-11:20     Q & A

11:20-11:35     2) Matthew Blurton-Jones (UC Irvine, USA)
Topic: Microglial Like Cells from IPSCs

11:35-11:40     Q & A

11:40-11:55     3) Gareth Howell (The Jackson Laboratories, USA)
Topic: The complement cascade in Alzheimer's disease and glaucoma.

11:55-12:00     Q & A

12:00-12:15     4) Christian Haass (DNZE, Germany) 
Topic: How does TREM2 tune the Innate Immune System?

12:15-12:20     Q & A

12:20-12:35     5) Catherine Bowes Rickman (Duke University, USA)
Topic:  Alternative complement pathway in age-related macular degeneration and its connection with Alzheimer's disease.

12:35-12:40     Q & A

12:40-1:00 pm Section II Discussion/Q&A

1:00 pm-2:30pm LUNCH

 

SESSION III - PROTEIN AGGREGATION IN BRAIN DISEASES: CAN WE USE THE EYE TO DIAGNOSE COGNITIVE DISORDERS? (Moderator: Adriana Di Polo)

2:30-2:45         1) Francesca Cordeiro (University College London, London, UK)
Topic:  Visual and ocular manifestations of Alzheimer's disease

2:45-2:50         Q & A

2:50-3:05          2) Brad Hyman (Harvard Medical School, Cambridge, USA)
Topic: High-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.

3:05-3:10         Q & A

3:10-3:25         3) Adriana Di Polo (University of Montreal, Montreal, Canada)
Topic:  Tau accumulation and retinal dysfunction in glaucoma and Alzheimer's disease.

3:25-3:30         Q & A

3:30-3:45         4) Laura Gasparini (Istituto Italiano di Tecnologia, Genova, Italy)
Topic: Tau-driven retinal dysfunction on tauopathies

3:45-3:50         Q & A

3:50-4:05         5) Frédéric Mascarelli (Centre de Recherche des Cordeliers, Université Paris Descartes, Université Pierre et Marie Curie, Paris, France)​
Topic: The role of amyloid beta in synaptopathy and congenital retinal degenerations

4:05-4:10         Q & A

4:10-4:30 PM Section III Discussion/Q&A

4:30-5:30 PM         COFFEE BREAK AND CLOSING REMARKS/DISCUSSION

To register for the workshop, please click here

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